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Although there have been numerous studies of the accuracy and precision of videokeratoscopes with inanimate test objects, little information exists on their precision (repeatability) for real eyes. Environmental pollution and shipping feasibility of the Nicaragua Canal. Giant cell tumor (GCT) of bone is locally aggressive benign tumor involving the epiphysis of long bones in young adults. Tissue factor expression in human umbilical vien endothelial cells stimulated by TNF-alpha and its molecular mechanism

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Histological appearances of the spleen and lymph nodes were analysed in twenty fatal cases of human visceral leishmaniasis from Sudan. COX-2 inhibition reversed melanoma-induced suppression of macrophage function, and combined treatment of IFN gamma plus a COX-2 inhibitor was maximally effective in reducing tumor growth and improving survival. Due to its location close to the main site of reactive oxygen species, the inner mitochondrial membrane, mtDNA is more susceptible than nuclear DNA to oxidative damage. A positive correlation between the biogas circulation rate and H(2)S removal rate was observed.

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A number of studies have highlighted an association between increased variability of blood glucose (BG) concentration and mortality, supporting a survival disadvantage if BG homeostasis is lost. Although available for commercial use, home test kits have not been shown to predict fertility or infertility in the general population.

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This may be partly a result of inadequate access to diagnostic sleep services. Considering our data of blunted histologic hepatotoxicity with omega-3 fatty acid supplementation, we hypothesize that this may be a method of reducing long-term complications of liver injury secondary to diseases of cholestasis such as biliary atresia, namely fibrosis and cirrhosis.

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aureus seems to be a rational approach for the control of staphylococcal mastitis. The existence of chitinase genes in mammals is intriguing and the physiologic functions of chitinases are not clear. GABA(B) receptors are a member of the G protein-coupled family of receptors which are generally considered to be excellent drug targets.

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These outflow apparatuses were additionally characterized by compressed, less organized trabeculae with a concomitant build-up of extracellular materials. Hemoglobin correlated independently with retinal vascular fractals indicating a relationship between hemoglobin availability and retinal vascular structure.

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The large majority of yeast infections are due to a few opportunistic species presently classified within the genus Candida, and occur in immunocompromised patients. The present work evaluates correction feasibility and performance for quantitative diffusion parameters of the two-component IVIM model for well-perfused and nearly isotropic renal tissue. Nonetheless, while challenging, this clinically relevant model has proven valuable for identifying mechanisms of acute and progressive neuropathologies as well as for the evaluation of noninvasive diagnostic techniques and potential neuroprotective treatments following TBI.

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The expression of this ET-B receptor in cultured amnion cells was down-regulated by the addition of EGF, but not by ET-1, IL-1 or A23187. Ninety-three patients, with normal uterine shape confirmed by examination and who were planning to undergo assisted conception treatments, were selected as research subjects. The ability to provide the latter in a discrete fluidic system presents a significant challenge.

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Effect of propofol on perception of pain in mice: mechanisms of action. Because these patterning processes require the interaction of hundreds of cells, it is impossible to estimate on a purely intuitive basis if a particular scenario is plausible or not. In most cases, these are only mild or transient and most reactions being irritant rather than allergic in nature. As for the interaction modes of the ecosystem services, 24 counties were primarily of regulation services, 3 counties were of supply and regulation services in balance, and 4 counties were primarily of grain supply.

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Expression of these sequences may protect cells when they are exposed to specific stress stimuli. In the present studies, we explored whether establishing chimerism by nonmyeloablative conditioning would induce tolerance to CTA. Performance on the same questions was assessed in a surprise test and a retention test.

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These findings begin to identify stromal miR-21 as a marker to guide chemotherapy choice in PDAC patients. The surface concentration and conformation of thiol-terminated poly(ethylene glycol) (PEG) on gold nanoparticles are studied before and after coadsorption of alkane-thiols. In addition, older immune therapies have also been used in these malignancies. Thalassemia intermedia resulting from a mild beta-thalassemia mutation. Central nervous system processing of human visceral pain in health and disease.

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Biological variation analysis (BVA) module of DeCyder was matched gel 1 and gel 2 images to provide data on differential protein expression levels between the two groups. Current platforms for augmented reality surgery fuse pre-operative radiographic studies but are limited with their ability to update with intra-operative imaging.

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Mars recalls pet food because of potential link with human illness. Though these observations do not differentiate between axon branching and looping of sensory axons into the ventral root as a cause of the proximodistal increase in numbers, they tend to support the former. The cellular and molecular mechanisms that underlie age-dependent osteoporosis, the most common disease in the Western Hemisphere, are poorly understood in part due to the lack of appropriate animal models in which to study disease progression. Proinflammatory T helper 17 (Th17) cells control infections caused by microbial pathogens. We also discuss the future directions of nanotechnology within the context of radiation oncology.

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Chicken heterophil extracellular traps (HETs): novel defense mechanism of chicken heterophils. Remarkably, it appeared that there are at least 3 clusters of co-occurring microbial species, termed enterotypes, that characterize the intestinal microbiota throughout various continents. The devices show no electroluminescence degradation neither under multiple bending down to 3 mm curvature radius nor in time for more than one month storage in ambient conditions without any protecting encapsulation. Show me the child at seven: the consequences of conduct problems in childhood for psychosocial functioning in adulthood.

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This powerful result shows the potential of linking these two models. However, less is known about neural, hormonal, and behavioral changes that occur as a function of parity-the number of children a woman has. During surgery, there was complete pancreatic necrosis in seven cases and incomplete in the other four cases.

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DIAPHRAGMATIC HERNIA: REPAIR BY TWO-STAGE OPERATION EMPLOYING PRELIMINARY EXTRA PLEURAL THORACOPLASTY. darlingi were used to test the hypothesis of ecological adaptation to human modified (highway) compared with wild (riverine) habitat, linked to forest cover.

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Augmenting CRISPR applications in Drosophila with tRNA-flanked sgRNAs. Although LKB1 (also known as STK11) is sufficient to initiate polarity in a single mammalian intestinal epithelial cell, its necessity in the formation and maintenance of mammalian epithelia remains unclear.

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Conditioned stereotypy: behavioral specification of the UCS and pharmacological investigation of the neural change. Comparative study of utero-inhibiting action of two beta-adrenomimetic drugs. This review has been undertaken to assess the available evidence for the benefits and harms of laparoscopic surgery for benign ovarian tumours compared to laparotomy. Early in the evolution of medical decision analysis, computers were employed to remove the tedium and insure the accuracy of repetitive calculations, a capacity they still serve today.

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Effect of 1,3-butanediol on rat liver microsomal NDMA demethylation and other monooxygenase activities. Almost all ED physicians showed better performance scores when not assisted by trainees or ED fellows.

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We assessed whether the risk for SCA is increased in epilepsy by determining the risk for SCA among people with active epilepsy in a community-based study. Nonactin, produced by Streptomyces griseus ETH A7796, is a macrotetrolide assembled from nonactic acid.

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Thus, loss of Nrf2 increased R-Smad phosphorylation and R-Smad signaling, supporting the hypothesis that loss of Nrf2 in an oncogenic context-dependent manner can enhance cellular plasticity and motility, in part by using transforming growth factor-beta/Smad signaling. Since then they have been facing the challenge of reorganizing disordered health services into a cohesive, regulated and sustainable health care system. 1) Should breast irradiation be given to women with early stage invasive breast cancer (stage I and II) following breast conservation surgery (lumpectomy with clear resection margins and axillary dissection)? We reviewed data for the following: exposure intent, exposure substance, outcome, age, code status, date of DNR/withdrawal of care order, previous suicide attempts, and poor prognostic signs. GRAIDs: a framework for closing the gap in the availability of health promotion programs and interventions for people with disabilities.

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Coronary in-stent restenosis (ISR) is a clinical problem for which a satisfactory solution has not been found yet. WBCT in high-energy trauma does not affect patient care if the patient is mentally alert, not intoxicated nor shows signs of other than minor injuries when evaluated by a trauma-team. Carboxymethyllysine-hemoglobin (CML-Hb) levels were measured by the dot blotting method using this antibody. This effect, that was different from that observed after hippocampal lesions but similar to that observed after caudate lesions, confirms the role of the basal ganglia catecholaminergic system in the development of the motor stimulation consecutive to the administration of this opiate receptor agonist.

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Initial themes in head and neck cancer clinical trial development were first identified along with examples. Optimization of catechol production by membrane-immobilized polyphenol oxidase: a modeling approach. Among them, exotic seed chalcids in the genus Megastigmus invaded Europe as a result of the rapidly-increasing and mostly unregulated seed trade for afforestation and ornamental plantations.

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Dietary habits, particularly a high sodium intake, may commonly contribute to hypercalciuria in patients with calcium oxalate stones. The effects of prostaglandins (PGs) E1, E2 and F2 alpha on the oxidation of labelled glucose in uterine strips from ovariectomized rats, were explored. Vitamin niacin, which is formed in greater amounts from trigonelline during the roasting process, may also be important from the nutritional standpoint. In contrast to other vasodilators, beta 1-agonists and phosphodiesterase inhibitors increase myocardial oxygen consumption independently of changes in the stress-time integral.

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The amphiphilic molecules self-assemble into vesicles with bilayer structure. Minimally invasive surgery that involves a combination of osteotomies, interbody height restoration, and advanced fixation techniques may achieve this goal in patients with less severe deformities. NMDA-induced internalization of pHluorin-tagged AMPA receptors (GluR2) was impaired in KO neurons. Patients with dyslipidemia who have not achieved treatment targets with monotherapy may benefit from the combination of these agents.

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Recent work has demonstrated that hydrogen peroxide functions as a signaling molecule controlling different essential processes in plants and mammals, which can be produced by superoxide dismutase (SOD) and xanthine oxidase (XO) and decomposed by catalase (CAT), respectively. When a device is in a low-resistance state, the tunnel barrier controls the current behavior of the device because most of the bias is applied to the tunnel barrier owing to its higher resistance. The national occupational therapy practice analysis: findings and implications for competence.

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However, these suggest that both central and peripheral chemoreceptor functions are generally defective in all states in children with CCHS. Single bolus intravenous regadenoson injection versus central venous infusion of adenosine for maximum coronary hyperaemia in fractional flow reserve measurement. Intermittent screening and treatment or intermittent preventive treatment with dihydroartemisinin-piperaquine versus intermittent preventive treatment with sulfadoxine-pyrimethamine for the control of malaria during pregnancy in western Kenya: an open-label, three-group, randomised controlled superiority trial. tuberculosis growth, adds new insights into a vital mycobacterial pathway, which may inspire new drug discovery strategies.

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Rupture of the tissue occurred following laminate debonding by shear and fibre slippage through the viscous ground matrix. Transgenic Cotton Plants Expressing Double-stranded RNAs Target HMG-CoA Reductase (HMGR) Gene Inhibits the Growth, Development and Survival of Cotton Bollworms. Several phase I studies have shown T-DM1 is safe, tolerable and has activity in trastuzumab- and lapatinib-pretreated breast cancer. Preface for small-molecule activation: from biological principles to energy applications. Rheumatoid arthritis (RA) is associated with increased mortality and morbidity because of accelerated atherosclerosis.

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These results suggest that flurazepam acts at a site other than the CCKA receptor itself to block CCK responses in the dorsal raphe. Premorbid warfarin use and lower D-dimer levels are associated with a spontaneous early improvement in an atrial fibrillation-related stroke. As such, methods that are compatible with the in situ hybridization procedure are included for staining astrocytes and microglia. Three different classes of molecules with well-known endocrine activity (iprodione, procymidone, vinclozolin, and a selection of their metabolites) were evaluated. Both laparoscopic and robotic hepatectomy are safe and their perioperative outcomes are comparable and favourable.

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Strained Allenes as Dienophiles in the Diels-Alder Reaction: An Experimental and Computational Study. The overlap priors lead to a LV tracking which is more versatile than existing methods because the solution is not bounded to the shape/intensity characteristics of a training set.