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To date over 140 different disease-causing mutations have been identified in the skeletal muscle alpha-actin gene ACTA1. Lipid-lowering effects of TAK-475, a squalene synthase inhibitor, in animal models of familial hypercholesterolemia. Organ culture in TGF-beta1, beta2, or beta3 induced myofibroblast transformation of corneal endothelial cells, with formation of stress fibers containing alpha-SM actin, loss of normal pericellular ZO-1 organization, development of extracellular fibronectin fibrils, and formation of focal contacts as indicated by punctate vinculin staining. The effect of NaCl substitution with KCl on Akawi cheese: chemical composition, proteolysis, angiotensin-converting enzyme-inhibitory activity, probiotic survival, texture profile, and sensory properties.

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The study comprised 37 patients with rheumatoid arthritis and 30 healthy controls. These resolution methods are heuristic evolving latent projections (HELP), sub-window factor analysis (SFA), and orthogonal projection resolution (OPR).

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Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data. Paired-sampled t-test was used to compare responses to both exercise tests while chi-squared test was used to compare categorical variables.

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will be submitted for approval under section 351(k), a newly created biosimilar regulatory pathway. Excitability and axon/dendrite specification are the most distinctive features in the establishment of neuronal polarization. Is self-determined functioning a universal prerequisite for motive-goal congruence?

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Personality preference type was not associated with resident performance on standardized examinations, but it was associated with faculty evaluations of resident performance. In rural Malawi, partner involvement in obstetric decision making was associated with improved obstetric choices.

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To compare the quality of life of heart, lung and liver transplant patients in New Zealand before and after transplantation and in comparison with New Zealand normative data for the general population. Diethylstilbestrol affects LGR8 expression in mouse gubernaculum testis

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Glutamate transport by high-affinity, sodium-dependent and by sodium-independent systems was shown. MSCTA performed using the novel software appears to be an alternative to other diagnostic methods of examining patients presenting with occlusive diseases of the lower limb arteries. Changes in collagen fiber crimp under equibiaxial strain suggest that, at the meso-scale, fiber deformations follow the global tissue strains. Thus, this paper focuses on the importance of protein palmitoylation in the pathogenesis of apicomplexan parasites.

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To describe rates of and reasons for follow-up among adolescents and adults receiving contraceptive implants in a Federally Qualified Health Center (FQHC). The aims of this study were (1) to develop a virtual system to evaluate the subjective visual vertical exam, (2) to provide a simple tool to clinical practice and (3) to assess the subjective visual vertical values of healthy subjects using the new software.

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tsutsugamushi would be more desirable for preventing scrub typhus in endemic areas. Although a large variety of inhibitors of these pathways have been commercialized, some of those inhibitors present severe side effects, governing the search for new molecules, as alternative anti-inflammatory agents. The objective of the present study was to evaluate whether the outcomes of lung transplantation in patients aged 70 years or older have changed after implementation of the lung allocation score in May 2005.

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A new method for determining the acid values (AVs) of edible oils based on the OH stretching band was developed. Post-translational polypeptide tagging by conjugation with ubiquitin and ubiquitin-like (Ub/Ubl) molecules is a potent way to alter protein functions and/or sort specific protein targets to the proteasome for degradation. In addition, the proposed scheme decreases both the clustering overhead and the average distance between cluster heads and their members. To minimize risk of harm to ovarian function and fertility for patients in this setting, careful considerations should be made. Results revealed that the rate of continuation and rate of on-time injections was almost similar between the two groups.

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The theory of combining the procedures of laparoscopy and endoscopy to identify and treat malignant lesions of the gastrointestinal tract is described as well as the techniques, advantages, and problems encountered. Conversely, the age of the subjects was significantly correlated with several markers of genomic instability, such as the incidence of chromosome X and chromosome 18 hyperploidy, total hyperploidy and polyploidy, and close to statistical significance with chromosome loss. Health care utilization by children with chronic illnesses: a comparison of medicaid and employer-insured managed care. Acinetobacter baumannii: a nosocomial pathogen difficult to control

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Defined daily dose (DDD) for each drug was assigned, and DDD per 1,000 inhabitants per day (DID) was used as a measurement unit. These emerging markers may aid in the earlier detection and intervention of subclinical CHD.

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All patients were devoid of any major past or ongoing disease and dyspepsia-associated diseases were excluded. To estimate the magnitude and distribution of disability due to road traffic accidents according to socio-demographic variables, and its main socioeconomic and health determinants. To date there is limited scientific evidence of health issues, and no mechanism by which mobile phone radiation could influence cancer development. Spatial and seasonal distribution of organochlorine pesticides in the sediments of the Yangtze Estuary. The study is a randomised, single-centre, double-blind, placebo-controlled, parallel-group clinical trial to evaluate the effect of rosiglitazone on integrated cardiovascular performance in a cohort of patients with type 2 diabetes mellitus (T2DM) at increased risk for developing heart failure (HF).

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However, these recurrent mtDNA mutations account for only a minority of mitochondrial disease cases. Both models adjust for patient and health-related characteristics, and for the dependency of LOS outcomes nested within hospitals.

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The molecular characterization of patients and knowledge derived from animal models of HPS contribute to the understanding of biogenesis and function of the LRO. The etiology of viral blips is currently unknown, but viral blip frequency inversely correlates with the decay of the latent reservoir, whose stability has been proposed as the major hurdle to HIV eradication.

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Although heavily involved in the care of their elderly patients living with cancer, the GPs who participated reported feeling isolated in their role at each step during the course of the disease. Group O whole blood sample was collected from 80 volunteers blood donors. Multivariate analyses of cocitation data suggest that major focus areas within the field include biomedical engineering, biomedical computing, decision support, and education. For both sexes, this share decreases as income and education levels rise, and it is higher among younger individuals, especially among those living in rural areas and in the Northeast region of the country. Occurrence of dead core in catalytic particles containing immobilized enzymes: analysis for the Michaelis-Menten kinetics and assessment of numerical methods.

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However, few studies addressed the effect of MSCs on osteoclastogenesis and bone resorption. At the same time, the two professional groups are obligated to reflect upon their critical attitude and take a proactive role in the development of appropriate quality indicators for the publication of quality data in Switzerland.

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Careful interpretation of growth hormone assays is still required, therefore, especially when results from different laboratories are being compared. This review will discuss current developments and potential future uses of PET/CT and PET/CMR for cardiovascular applications, which promise to add significant incremental benefits to the data provided by each modality alone. Moreover, Smad2 shows predominant nuclear localization in freshly isolated cGC, indicating active Smad signaling in vivo. We report the first case of left cerebral hemiatrophy and a late onset of treatment-resistant schizoaffective disorder after a stressful life event.

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These subjects demonstrated moderate reliability for cadence and poor reliability for speed and stride length. One hundred seventy-eight hospital-based asthmatic children and 277 community-based controls aged from 5 to 12 years were recruited in southern Taiwan. Lamivudine was well tolerated for a median duration of 8 months (range, 4-14 months) without significant side effects. We demonstrate rheological measurements to be capable of detecting cellular debris along with a discriminative capture of DNA and protein ratios.

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IGF-I was more potent than insulin at stimulating B104 cell replication in serum-free medium and, at an initial concentration of 100 ng/ml, was the only exogenous growth factor needed to maintain growth through several cell divisions. Many risk factors are associated with the development of future adverse CV events, such as age, hypertension, body mass index, and other comorbidities.

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Expression of the homeobox gene GBX2 during chicken development. The profile of the number of cells in each layer of the gel provided additional discrimination between the different cell lines. However, CCN2 can be expressed in a variety of cell types, and the contribution of CCN2 derived from either tumor cells or stromal cells as it affects the growth of pancreatic tumors is unknown.

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In two small cell lung cancer cell lines tested so far, pretreatment with interferon alpha was found to increase the radiation sensitivity without altering the distribution of cells in the cell cycle. INCREASE OF BLOOD BILIRUBIN FOLLOWING IRRADIATION OF THE RAT BY X-RAYS One month after the last drug infusion and 18 months from starting treatment, the patient presented with eosinophilic fasciitis. Management of alcohol use disorders in ambulatory care: Which follow-up and for how long? 134 consecutive patients entering a pulmonary rehabilitation program were recruited.

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Despite the extensive use of retinal photocoagulation for ischaemia and vascular leakage in retinal vascular disease, the molecular mechanisms behind its clinical beneficial effects are still poorly understood. We find no evidence for population growth near protected areas to be greater than growth of rural areas in the same country. Comparisons of tropical savanna systems: key questions and challenges.

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The aim of our study was to record indications and complications of PEG-placement in a one-year period. Different examples of studies applying the 2 methods are illustrated, by stressing the advantages and the pitfalls of both. Ame1-Okp1 directly associates with the centromere protein C (CENP-C) homologue Mif2 to form a cooperative binding platform for outer kinetochore assembly.

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Subcutaneous administration in rats showed extended stability and sustained release of these ligands. There were 42 cases diagnosed from 1975 to 1991 in patients who had arrived from Asia and Africa. For these purposes, we used multidrug resistant (MDR) and non-MDR tumor and leukemia cell lines and the MTT-microcultured tetrazolium colorimetric assay. Diagnostic tests of interest were items of medical history and physical examination.

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Exogenous H2S protects against HG-induced injury by inhibiting leptin/LEPR pathway in HUVECs. Elevated concentrations of homocysteine are associated with cerebral small vessel disease (CSVD). TGF-alpha mRNA expression in the exposed epithelial cell monolayers was assessed using reverse transcriptase-polymerase chain reaction (RT-PCR) and normalized to the expression of glyceraldehyde-3-phosphate dehydrogenase (GAPDH).

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To reduce the time complexity of training and testing for KRR, a sparse solution is found by combining the ideas of kernel matching pursuit and gradient descent. We report a case of GCGBM presenting primarily as an extraaxial bilateral CPA tumor in a 29-year-old woman with neurofibromatosis Type 1 (NF1). Investigations of arterio-venous anastomoses in the spermatic cords and blood supply, oxygen consumption and testosterone production of scrotal and abdominal testes in the pig. Microwave emission spectrum of the moon: mean global heat flow and average depth of the regolith.

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A novel Pro126His mutation in alphaIIb compromised transport of the pro-alphaIIbbeta3 complex from the endoplasmic reticulum to the Golgi, leading to intracellular retention. LLM can be used to diagnose aspiration in reflux-related chronic cough.

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Removal torque test and the BIC was histologically evaluated at 0 and 8 weeks. Evaluation of the Green Dot Bystander Intervention to Reduce Interpersonal Violence Among College Students Across Three Campuses. NaCl fibrils, which are less stable than the other fibrils, have a large and positive C(p).

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It allowed for a clear-cut positioning of the endotracheal tube. A survey of leprosy deformities among the patients of Hyderabad city. While at least 6 orthologs and paralogs are present in mammals, C. The development of adolescent drinking behavior: an evaluative review of the impact of the socialization process within the family. It is essential to pay attention to and respect the dignity of nurses to maintain them in their profession while they deliver skilled nursing care.

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Results provide support for the feasibility and applicability of virtual technology to real-life communication contexts to improve functional communication in PWAs. The proposed BLU shows normal directional light emitting characteristics to both the front and back sides of the LGP and successfully acts as a planer light source for a dual-sided LCD.

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Surgical repair is feasible through a sternotomy or thoracotomy incision. What is needed, among others, is to eliminate the autonomous cardiac effect through pharmacological blockade by means of the parasympathetic atropine and the beta-receptor blocker propanolol. The primary objective was to evaluate sites, with evaluation of track geometry a subordinate objective made necessary by anatomical differences.

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This reactivity with some degree of tumor specificity may be a leukemic equivalent to responses reported for populations of tumor infiltrating lymphocytes (TIL) seen in some solid tumors. Here, we demonstrate that the purple pigment produced by TC14 is violacein. Temporal patterns were assessed for 37 countries using data from Cancer Incidence in Five Continents (CI5) volumes I-X and the WHO mortality database. In the absence of a functional septation apparatus, mnn10 mutants are unable to complete cytokinesis and die as cell chains with incompletely separated cytoplasms, indicating that mannosylation defects impair the ability to form remedial septa.

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The research was initiated in early 2013 and completed in early 2014 in each of the 6 study clinics and consisted of (1) patient flow mapping and measurement of retention through collection of health systems data from antenatal care registries, pharmacy registries, ART clinic databases, (2) workforce assessment and measurement of patient waiting times, and (3) patient and worker individual interviews and focus groups. Because SLC6A14 is essential for tumour growth yet dispensable for normal development and tissue maintenance, small molecules that block amino acid import through this transporter could be effective and selective anti-cancer agents, particularly as components of rational drug combinations. On one hand, the reaction can be initiated with electrophilic halogenation at an alkyne or alkene moiety.

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Immunogenicity and immune modulatory effects of in silico predicted L. Investigation report on the technical standards of TCM diagnosis, treatment and rehabilitation equipment

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Finally, the LTM can be extended to the case of flexural waves propagating in anisotropic thin plates. Long-term outcome of basilar stenosis in Erdheim-Chester disease: A case report. A specific inhibitor of HO-1, Zn(II) protoporphyrin IX, blocked the suppression of NO production, cytokines release and iNOS expression by brazilin.

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In September 2001, scientists from around the world met in Melbourne to discuss the mechanisms underlying neuronal and vascular changes in diabetic complications. Whole-pelvis Radiotherapy in the Radiation Treatment of Intermediate- and High-risk Prostate Cancer: How to Improve the Therapeutic Ratio of a Potentially Effective but still Unsatisfactory Treatment?