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Topigen (Topiramate)
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Topiramate

Topigen is a sulfamate-substituted monosaccharide with anticonvulsant property. Although the mechanism of action has not been fully elucidated, Topigen antagonizes kainate/AMPA subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (GABA) activity and thereby attenuating GABAnergic inhibitory transmission.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Mutation of Ser(334) and Ser(335) also greatly reduced nociceptin-induced ORL1 phosphorylation. Increased amount of target, alteration in structure of target proteins, decreased drug uptake and increased detoxification are well-known mechanisms of resistance. This is the first study to use all available criteria to estimate the prevalence of PCOS.

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No effect on bacterial load was identified, however with a larger sample size this may be noted. Predictors of referral for adjuvant therapy for colorectal cancer.

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Semi-structured qualitative interviews were administered to a convenience sample of 41 CRC patients who were 0-24 months post-treatment. Therefore, STAT5 functions at a distinct step in regulating distal V(H) recombination in relation to the transcription factor Pax5 and histone methyltransferase Ezh2. Linking reliability measurement to standardization at an institutional level may lead to safer care. Unfortunately, the costs associated with high failure rates for investigational compounds as they enter clinical trials has led to pharmaceutical companies downsizing or eliminating research programs needed to develop these drugs. In summary, we have discovered a promising class of potent antibacterials with a previously undescribed mechanism of action.

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A questionnaire consisting of ten questions was designed to identify their knowledge about the existence of pain clinics and pain physicians. An overall decrease in the efferent neurotransmission of these two brain regions results in a strong anticonvulsant effect indicating their importance in modulating limbic seizure activity.

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Interviews were recorded and transcribed, and analysed using a thematic framework approach. Regulation of glucose transport activity and expression of glucose transporter mRNA by serum, growth factors and phorbol ester in quiescent mouse fibroblasts. The aim of this study was to demonstrate the efficacy of elective total hip arthroplasty in patients aged 80 years or older with end-stage hip arthritis.

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Forty-one federal laws produced between 2002 and 2012 were identified. We suggest that the discussion of the model of differentiated attention should strengthen the relationship between the health system and the selfcare. Taking into consideration the results of specific investigations, we hypothesise that the non-uniform spatial distribution of grass roots within the studied soil can play an important role in influencing this phenomenon, while several abiotic factors do not play any significant role. In particular, new knowledge concerning the usefulness of markers of bone turnover and of the effectiveness of antiresponsive strategies should greatly improve our ability to prevent osteoporotic fractures. Virtual sectioning of cardiac tissue relative to fiber orientation.

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To assess the medial laxity of knee joint, medial joint space opening (MJO) was measured while valgus stress of 15 kgf was loaded on the knee joint. In view of the documented effects of GH, PRL, and thyroid hormones on lean and fat body mass and skeletal growth, and the suspected relationship of body size and composition to life expectancy, it was of interest to examine age-related changes in body composition of Ames dwarf mice. Six sugars (sucrose, maltose, lactose, glucose, galactose and fructose) produced the depolarization responses. A static immersion test combined with the nickel ion release measurement seems to be more relevant for the determination of biocompatibility than the electrochemical testing.

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A double-blind study of adjunctive carbamazepine versus placebo on excited states of schizophrenic and schizoaffective disorders. The procedure guideline for radioiodine therapy of differentiated thyroid cancer (version 4) was developed in the consensus of a representative expert group. Pre- and postoperative nasality and nasal airflow using the CAPS score, assessment of nasendoscopy recordings, and the rate of further surgery. Findings suggest that youth reported a wide variety of experiences as traumatic that could be reliably coded and classified, and that youth reporting traumatic events and symptoms consistent with PTSD evidence higher levels of emotional, and behavioral problems (via parent and child report) than youth not reporting traumatic events.

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Here, we have investigated the roles of COP1 and the COP1-interacting SUPPRESSOR OF PHYA-105 (SPA) proteins in seedling and adult facets of the shade-avoidance response. Transforming traditional Tai Ji Quan techniques into integrative movement therapy-Tai Ji Quan: Moving for Better Balance. The mechanism proposed is a protein-induced change in vesicle morphology that corresponds to reduced curvature. 2c deviation index and 5c exceeding rate, were predictors of poor survival in NSCLC patients.

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For the first time, two dimensional fluorescence difference gel electrophoresis was used to study the plant mitochondrial complexome in heat and heat recovery. The local reaction of the skin after injection of vaccine increased from 1.67 to 4.05 cm2 in 8 weeks. PEG-Phospholipids Coated Quantum Rods as Amplifiers of the Photosensitization Process by FRET. The Tn vaccine effectively elicited high-titer IgG1 antibodies against Tn in immunized mice, and effectively suppressed the development of prostate cancer in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) mice.

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Adequacy of cementation was assessed on immediate postoperative radiographs. After adopting the Guidelines for the Management of Severe Head Injury, critical care physicians in Argentina reduced the mortality rate of patients with traumatic brain injury (TBI). This study confirms that human mononuclear cells express the mu opiate receptor transcript and demonstrates that nitric oxide is involved in regulation of its expression. Flavonoids are considered as potent anti-photoaging agents due to their UV-absorbing and antioxidant properties and inhibitory activity against UV-mediated MMP induction. The steric hindrance is higher in the case of harmine due to the presence of methoxy group on the beta-carboline ring.

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Selection of good producing clones was performed by immunoblot analyses of the supernatants from shake-flask fermentation. The effect of age on coordination of stabilization during changing environmental dynamics. We have previously shown that N(6)-methyldeoxyadenosine (MDA) is an inducer of differentiation in several tumor cells. Driving Self-Restriction and Age: A Study of Emergency Department Patients. Otherwise, (131)I scintigraphy can exclude thyroidectomy when reveals uptake in the nodule, which is observed in half the cases.

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Effect of glutathione and sodium selenite on the metabolism of arsenic in mice exposed to arsenic through drinking water Using the revised Illness Perceptions Questionnaire (IPQ-R) and the Diabetes Illness Representations Questionnaire (DIRQ), participants completed measures of: perceived duration of diabetes (timeline IPQ-R), understanding of diabetes (coherence IPQ-R), personal responsibility for influencing diabetes (personal responsibility IPQ-R), seriousness of diabetes (seriousness DIRQ) and impact on daily life (impact DIRQ), before and after the education programme. Lethal course of X-linked dominant chondrodysplasia punctata in a male newborn. This seems to be the first example of pupillary enlargement as a false localising sign from a contralateral, supratentorial, intraparenchymal mass lesion. In the present work, we have exploited the mouse model of persistent infection by mouse-adapted H.

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Regenerated cellulose/multiwalled carbon nanotube composite films with efficient electric heating performance. In view of high informative value of the method, ultrasonography is recommended as a substantial component of the early diagnosis. In view of the accumulation of H2O2 in the myocardium due to ischemia-reperfusion and changes in beta-adrenoceptor mechanisms in the ischemic-reperfused heart, we investigated the effects of H2O2 on the beta-adrenoceptor, G-protein and adenylyl cyclase complex. The aim of this study was to explore this problem under controlled conditions using a human centrifuge.

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The precise localization of the favorable DCS allowed a detailed analysis of pleiotropic effects and the study of the consistency of effects for per se and testcross performance. Effect of beta-adrenoceptor antagonists and some related drugs on maximal electroshock seizures in mice.

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Since 1970, more than 4,500 patients have been patch tested at the Contact Dermatitis Investigation Unit in Glasgow. Candida albicans mycotic aneurysm associated with systemic lupus erythematosus. Analysis of beta-glucosidase activity in the bench-scale samples demonstrated that it was the assay temperature, rather than the in situ composting temperature, which was more important in determining the level of activity. Yet, as a proliferative agent, mTOR can not only foster cancer stem cell development and tumorigenesis, but also mediate cell senescence under certain conditions to limit invasive cancer growth.

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Time trends in biochemical recurrence after radical prostatectomy: results of the SEARCH database. In Saccharomyces cerevisiae, there are two large subunits (Rnr1 and Rnr3) and two small subunits (Rnr2 and Rnr4). Coronary vasospasm related to 5-FU is a rare clinical entity in oncological practice and may be seen during both bolus and protracted infusional administration.

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To create a more realistic picture of the plume position, a series of direct-push monitoring wells were installed along one control plane. This presents quality issues, as well as medico-legal and safety concerns for the professional and patients alike. The timing and surgical management of neonatal testicular torsions (NTTs) remain controversial, varying from immediate orchiectomy with empirical contralateral orchiopexy to expectant management with resulting atrophy of the affected testicle.

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Using public-use data from the 2010 National Survey on Drug Use and Health, this study employed binary logistic regression with adjustments for complex survey sampling to assess relationships between never wearing a seat belt and sociodemographic variables, antisocial behaviors, substance abuse and co-occurring problems, and criminal justice system contact. The primary outcome of this study was the presence of in-hospital POD after TAVR.

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Selective suppression by bunazosin of alpha-adrenergic agonist evoked elevation of intraocular pressure in sympathectomized rabbit eyes. Hepatic wedge ablation appears to be a highly effective treatment for hepatic malignancies in the inferior margin and provides a better local control than conventional tumour ablation. To examine the relationship between surgical volume and complications and resource utilization for myomectomy.

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Dialyzer clearance K, V1 and V tot correlated inversely with percentage of protein binding. The possible mechanisms of these effects have been discussed in detail. Nevertheless, the therapist should always be aware that it is impossible to prevent all suicidal acts. SEM is employed to test the proposed mediation model, using a sample of 133 Hong Kong Chinese university students.

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Item-properties may influence item-item associations in serial recall. The statement draws on insights from the World Urban Campaign thinkers campus held during 24-27 January 2016 in Kuching, a WHO-designated healthy city. Cl(2) gas toxicity is complex and occurs during and after exposure, leading to acute lung injury (ALI) and reactive airway syndrome (RAS). Pharmacological therapy with GnRH analogues and the cryopreservation of ovarian tissue are discussed in this context.

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Because the anatomical position of the corpse cannot fully illustrate the actual clinical situation in vivo, the diversity of MTS has not been fully elucidated yet. These results suggest that CXCR3 and its ligands play an important role in the re-establishment of the basement membrane and epidermis.

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IL-8 and SEB did not significantly affect neutrophil deformability. To elucidate possible explanations for such improvements, here we have undertaken a study examining the effect of SDS micelles on peptide mixtures. Ferriman-Gallwey score before treatment, at 6 and 12 months of treatment, and 1 year after the end of treatment, and androgenic profile before and after treatment. Transcriptome Sequencing Analyses between the Cytoplasmic Male Sterile Line and Its Maintainer Line in Welsh Onion (Allium fistulosum L.). In cases, where the SMCV directly connects with superior sagittal or transverse sinus, SpBV or SpPS, surgeons have to meticulously select a safe and effective approach and take measures to preserve the SpBV or SpPS during surgery.

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Filaricidal activities on Onchocerca ochengi and Loa loa, toxicity and phytochemical screening of extracts of Tragia benthami and Piper umbellatum. Endoscopic treatment of recurrent sigmoid volvulus with colopexy assisted by T-fasteners and colostomy.

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These two effects of p27rex operated at the post-transcriptional level and were independent of transcriptional regulation. Textbooks regarding retinal detachment and the reference lists of relevant reports were reviewed in an effort to find additional study reports.

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Moreover, increased muscle resistance during passive extension measured mechanomyographically after this dose of CGS 21680 was observed. Recovery of functional dorsiflexion and improvement in gait was noted in eighteen of the nineteen cases. Post-processing of the alignments removes non-unique and low-quality mappings.

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A novel cytochrome b putatively involved in O2- generation was detected in U937 cells. These results should also lead to further work on an educational tool specifically designed for elderly diabetics. The tachykinins had no effect in direct and co-mitogenic T and B lymphocyte proliferation assays with rat spleen cells, in a thymocyte growth peptide assay with mouse thymic lymphoblasts or in an interleukin-2 (IL-2) bioassay with IL-2-dependent rat splenoblasts. Drug release behavior was assessed, in vitro, under simulating conditions in term of pH and time in vivo during transit to the colon.

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In particular, interferon-alpha (IFN-alpha) has been shown to inhibit the development and progression of cervical cancer. Aberrant growth of mossy fibers and enhanced kainic acid binding sites induced in rats by early hyperthyroidism. Visual acuity, macular degeneration and intraocular pressure were not related to early growth. Effects of high Gz acceleration can threaten flight safety through loss of consciousness or a lesser-known phenomenon, G-induced vestibular dysfunction (GIVD).

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Protective effects of a novel sea buckthorn wine on oxidative stress and hypercholesterolemia. This review identifies the current challenges in the investigation of VOCs as potential cancer biomarkers, by the critical evaluation of available matrices for the in vivo and in vitro approaches in this field and by comparison of the main extraction and detection techniques that have been applied to date in this area of study. We reported a 65-year-old man with peritoneal malignant mesothelioma which was discovered by hydrocele of left undescended testis.

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Adriamycin (ADM) is an antineoplastic agent that is effective against a wide range of cancers, but cardiac toxicity limits its clinical application. Diamicron offers advantages since it reduces blood glucose effectively, has few side effects and no evidence of long-term problems or toxicity. Cathepsin L, a lysosomal cysteine protease, is overexpressed in several cancer types. The study suggests that memory performance is not influenced by race and that race-adjustment may not be necessary in the norming of memory tests. Ionomer-Liquid Electrolyte Hybrid Ionic Conductor for High Cycling Stability of Lithium Metal Electrodes.

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Effect of the timing of admission upon patient prognosis in the Intensive Care Unit: (On-hours versus off-hours) and diurnal variation. Transcriptional response of stress-regulated genes to industrial effluent exposure in the cockle Cerastoderma glaucum. The different possible ablation approaches and their potential limitations are discussed.

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A primary reason for the negative financial performance is the high amount of nonreimbursed healthcare services-the clinic provides needed healthcare to a low-income part of the metropolitan area. Azide- and vanadate-sensitive M-phase alkalinity and cytosolic acidification of Chang liver cells. The successful application of different MS has been shown in different organisms, including insects, amphibians, plants, nematodes, and mammals, including humans. Parosteal osteosarcoma: report of a case and review of the literature. High resolution computed tomography in the study of the respiratory tract

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We report our first case of transanal endoscopic surgical treatment of RVF with a successful outcome. The versatility of the microparticles is demonstrated to be color-encoded, pore-controllable, bioactive, and potentially used as a DNA bioassay. This challenges the alleged shift from a dominant government towards collaborative governance and calls for detailed analysis of actual governance. However, osmotic oedema is not limited to extreme clinical circumstances. Additional determination of specific IgG or IgG4 levels was not useful in predicting tolerance development in our study population.

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The spatial distribution of annual mean temperature, annual rainfall, and some bioclimatic indices has been analyzed for the present (1970-1989) and future (2080-2099) climate under SRES A2 emission scenario. Phytophthora infestans secretes numerous RXLR effectors that modulate host defense and thereby pave the way for successful invasion.

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The weights are optimized using a modified perceptron error criterion and a conjugate gradient optimizer. Nonparametric statistical approaches are employed to evaluate the interrelationships and associations in structural variables.

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These potential applications will require more in-depth study and research, and will ultimately have to stand the test of time. She had near total restricted extra-ocular movements and mild proptosis of the right eye. Clearly, there is a need to identify, diagnose, and provide effective treatment of a depressed patient quickly. Specific inclusion bodies are associated with replication of lettuce infectious yellows virus RNAs in Nicotiana benthamiana protoplasts. Therapies directed against T-cells have been shown to halt the disease process and prevent recurrent beta-cell destruction after islet transplantation.

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By contrast, attitudes toward vasectomy were uniformly negative. A total of 589454 quality-filtered 16S rDNA sequence reads were processed through a NextGen 16S rDNA analysis pipeline. Recent randomised controlled trials (RCTs) suggested the non-inferiority of percutaneous left atrial appendage closure (LAAC) versus VKA. Atropine co-administration with HupA did not alter HupA-induced intracortical inhibition suggesting independent of muscarinic acetylcholine receptors mechanism in this model. Analysis of the gyrA and parC genes of Mycoplasma genitalium detected in first-pass urine of men with non-gonococcal urethritis before metronomic low dose cyclophosphamide injection and after fluoroquinolone treatment.

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Although previous studies reported addiction-related alteration in resting-state brain connectivity, it is unclear whether these resting-state connectivity alterations were associated with chronic heroin use. This study aimed to compare the efficacy and side effects of relatively low and high doses of Ganciclovir in the treatment of neonatal terazosina 5 mg para sirve el congenital CMV infection.

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Thyroglobulin measurement on fine-needle washout fluids: Influence of sample collection methods. In displaying the intracellular receptors for oestradiol and progesterone it attentrol vs adderall dosage shows that hormone receptivity was maximum in benign conditions as they were starting in young women with a short clinical history and with most marked cellular density on anatomo-pathological examination. The permselectivity of the PI membrane can be controlled by varying the amount of magnesium perchlorate in the casting solution and the relative humidity during the pre-gelation conditioning of the membrane. Moreover, the BDNF val66met polymorphism known to partially affect activity-dependent BDNF secretion impairs motor skill acquisition in humans and mice.

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