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A generalized estimating equations approach to quantitative trait locus detection of non-normal traits. In this study, we examined the effects of TSN on the growth, cell cycle arrest, induction of apoptosis and the involved signaling pathway in human promyelocytic leukemia HL-60 cells.

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The regimen was well tolerated and was associated with a decrease in viral burden. Human milk (HM) is the preferred basis of nutrition for infants, including those born prematurely. The aim of this study was to analyze diagnostic and therapeutic procedures and the outcome of patients treated for the most common malignant tumor of the facial skin, basal cell carcinoma.

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Self-esteem in children and adolescents differently treated for locomotory trauma. This study reports an intrapetrous facial glomus that occurred in a case of multiple paragangliomas with a hereditary pattern.

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Quality of care and patient safety initiatives identify human factors associated with team performance as a prime improvement area for clinical patient care. However, the structure and protein composition of HDL particles is complex, as native and synthetic discoidal and spherical HDL particles can have from two to five apoA-I molecules per particle. Sleep complaints and the use of sedative hypnotics in the elderly are now more frequent than in younger patients. A cytochrome P-450 N (N for Neonatal) was resolved and partially purified from 15-day-old newborn rat livers. Sensitivity analysis and statistical approaches were used to compare model simulated treatment results with the use of Coartem and other antimalarial drugs.

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The antibodies showed that types I and III collagens were abundant and distributed throughout the dermis. PET-CT is indicated for response evaluation in this setting to improve the accuracy of post-treatment assessment by CT. The effect of alloxan induced diabetes on the dermal collagen content of albino rats was studied in relation to few lysosomal enzymes. Defects in soluble NSF attachment protein receptor (SNARE)-mediated granule exocytosis occur in islet beta cells, adipocytes, and/or skeletal muscle cells correlate with increased susceptibility to insulin resistance and diabetes. In case of pulmonary disorders scuba-diving is contraindicated most of the time.

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Twenty-five healthy men were assigned randomly to oxycodone or placebo for 5 days in a cross-over design. Sugar tax campaigners plea for action ahead of obesity strategy. The GABAergic release could be modified by GABAA and GABAB targeted drugs.

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To compare the clinical and oncologic outcomes of robotic radical hysterectomy (RRH) vs abdominal radical hysterectomy (ARH) in patients with cervical carcinoma. EUS placement of metal fiducials by using a backloaded technique with bone wax seal.

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The immediate response to viral infection relies on pattern-recognition receptors (PRRs), most prominently the Toll-like receptors (TLRs) and the RNA helicases RIG-I and MDA5, as well as double stranded RNA-dependent protein kinase (PKR) and the DNA receptor, DAI. The influence of radiographic contrast media on some granulocyte functions. One complication of adenotonsillar hypertrophy that has not been previously reported in the English-language literature is transient cortical blindness.

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This was most likely due to that DCs with the conditionally ablated RBP-J were unable to evoke anti-tumor immune responses in the solid tumors. ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer. grandicollis using complementary correlative and manipulative approaches. Ab2 against Ab1 GA733 produced in goats have been previously shown in experimental animals to functionally mimic the epitope defined by the Ab1. The effect of rIFN-gamma was dose dependent, being half maximal at 2 U/ml, and required between 90 min and 240 min of incubation to reach optimal response.

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In such trauma case, the external pressurized air forms a shock wave which usually directed to the hollow viscus. These findings indicate that phMRI responses to activation of DA neurotransmission by GBR12909 or AMPH are overall identical in the awake state, while the phMRI response to a DAT inhibitor, GBR12909 but not to AMPH was changed by isoflurane anesthesia.

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A 74-year-old woman presented with progressive quadriparesis and sensory deficit after receiving acupuncture in the neck and shoulder. We demonstrated, for the first time to our knowledge, that Apo D was highly expressed in the mRNA and protein levels in human failing hearts compared with non-failing hearts. Adhesion to intestinal epithelium is an outcome property for the selection of probiotic lactic acid bacteria strains.

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Serum levels, ontogeny and heritability of chicken mannan-binding lectin (MBL). To study these processes, here we report the synthesis of four regioisomerically sulfated p-nitrophenyl glucosaminides from the common precursor p-nitrophenyl N-acetyl-beta-D-glucosaminide. An Azaacene Derivative as Promising Electron-Transport Layer for Inverted Perovskite Solar Cells. Being previously identified as overweight by a medical professional was associated with increased weight/shape concerns but not with current disordered eating behaviors or ED status.

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A geometrical core is defined as the set of residues such that the C alpha (I) - C alpha (J) atom distances are identical in all structures of the protein family under study, where I and J are secondary structure positions in the structural units--strands, loops, or parts of them. This proteolysis was concluded to take place either in the outer membrane or in the periplasm. Single factor analysis and the unconditional multivariate logistic regression were applied for analyzing the on the related social-psychosocial factors among high-risk pregnancy women. Thus, in this series of Comprehensive Physiology, the basic properties of cardiac muscle function, the cardiac cycle, and determinants of pump function will be reviewed. American Academy of Sleep Medicine (AASM) Position Paper for the Use of Telemedicine for the Diagnosis and Treatment of Sleep Disorders.

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Multilevel logistic regression analyses were employed to examine the associations between problematic CPU and risky behaviors and low self-esteem regarding gender and age. Combined transhepatic and transvenous approach to hepatic vein stenosis after transjugular intrahepatic portosystemic shunt (TIPS). Extirpation of the Rectum per Vaginam, with Utilization of the Vagina to replace the lost Rectal Tissue. Electrohydraulic lithotripsy of bladder stones was carried out successfully.

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In both cases frequencies obtained are the lowest of compared Spanish data. HA priming minimized the risk of clotting and enabled acute IHD in vulnerable patients without increased bleeding, thus allowing completion of IHD to the same extent as for standard HD. Subpixel detection is a challenging problem in hyperspectral imagery analysis. Sequential release of tumour necrosis factor, platelet activating factor and eicosanoids during endotoxin shock in anaesthetized pigs: protective effects of indomethacin. Oral administration of nicotine and plasma levels of ACTH and cortisol in smokers and non-smokers

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Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity. Conclusive diagnosis of hepatic and pancreatic malignancies by fine needle aspiration. During clinical follow-up, the patients were in a good condition with decreasing regional low back pain and no ongoing radiological changes in the affected vertebral bodies. These were compared with all patients undergoing THR and TKR in the 12-month period commencing 1 November 2013, and all patients waitlisted during this period but returned to GP due to capacity issues.

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Myocardial depression has been found in sepsis, which contributes as an added comorbidity in an already compromised heart function. The three factors allow us to differentiate between individuals who remain in the organization for a period of 12 consecutive months, and those who leave earlier. Maturation of those depends on accessory proteins encoded by hyp-genes. For the lowest dose used (10.75 Gy) no density increase was observed and in fact density decreased with time after irradiation to a slightly greater extent than in non-irradiated controls.

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The aim of the study was to evaluate the prognostic value of the initial transcriptional activity of IFNg and two subunits of its receptor as measured with the use of QRT-PCR and SYBRGreen chemistry in the group of 63 patients with clinically confirmed myocarditis who were treated with statin or immunosupressive therapy. The results showed that peripheral blood macrophages/monocytes, T-cells and B-cells become activated during acute KD in terms of numerical changes in immunocompetent cells, expression of activated antigens on the cell surfaces and cytokine production. Subjects preferred the smell, feel, and application of Products A and experienced significantly less irritation than Products B. In addition, the other known biologic properties of relaxin, including anti-inflammatory effects, extracellular matrix remodeling effects, and angiogenic and anti-ischemic effects, all may play a role in potential benefits of relaxin therapy.

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As they are likely to be poorly degraded in waste water treatment plants, significant amounts of EDTA and DTPA are released into natural waters. A huge number of Spanish surgeons have contributed to the implementation of techniques and spreading the knowledge of these concepts by means of courses, controlled randomized studies, scientific papers, and books, and have obtained international recognition. To conduct the experiments, two-chambered shuttle boxes were equipped with two operant levers (left and right) and a food receptacle in one chamber, which was then divided from the second chamber by an automated guillotine door covered by a wire grid. The osteomuscular anomalies of the chest, which are not demonstrated by usual x-Ray, are well defined by CT scans.

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Anti-inflammatory activities of vernocuminosides I and K-N were determined. Although the nature of the signals sensed by MASE1 and MASE2 is still unknown, MASE1-containing receptors appear to play important roles in bacteria, including iron and/or oxygen sensing by hemerythrine-containing proteins in the sulfate-reducing bacterium Desulfovibrio vulgaris. Based on the medical evidence derived from the scientific literature on this topic, there does not appear to be evidence to support the hypothesis that fusion (with or without instrumentation) provides any benefit over decompression alone in the treatment of lumbar stenosis in patients in whom there is no evidence of preoperative deformity or instability.

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The purpose of this study is to analyze the clinical presentation and surgical outcome of colloid cysts surgically managed over a period of thirty-two years and evaluate the technical issues based on our experience. We compared DW images and CT scans obtained with a short time delay in patients with acute stroke to define the sensitivity and interrater agreement of both imaging techniques. Inter-agency collaboration: teaching breast self-examination to black women. Occurring after a recent neurosurgical procedure, the intracranial hypotension is termed secondary. The complementary within-trial (compared with across-trial) data are interpreted with respect to a possible disturbance in inhibitory function in patients with schizophrenia.

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The odds ratio of a patient with LH expressing the HLA-DQ8 marker is 23.1-fold higher than that of a patient with another sellar mass. We assume that the exogenous supply of heme may improve cellular hypoxia. To investigate the microbiome composition in Chinese patients with aggressive periodontitis (AgP), and to compare the similarity of bacterial profiles between AgP patients and their family members. This may be due, in part, to the varying effects of differing fibers.

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In metazoans, nuclear export of bulk mRNA is mediated by Tap-p15, a conserved heterodimeric export receptor that cooperates with adaptor RNA-binding proteins. Temperature dependence on hydration kinetic model parameters during rehydration of parboiled rice.

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We present here results of coarse-grained protein-protein docking and molecular dynamics simulations of CXCL12 in association with CXCR4 in monomeric and dimeric states. Mir-55 inhibition can reduce cell proliferation and induce apoptosis in Jurkat (Acute T cell Leukemia) cell line. We recommend these issues to be further examined in a prospective longitudinal study since it may have important implications for sick leave frequency during pregnancy. We present a case of an Eastern European man with nasopharyngeal cancer and concurrent tuberculous lymphadenitis. One black-tip reef shark (Carcharhinus melanopterus) was found dead without previous signs of disease.

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Novel cellular assays, sensitive systems to probe function, emerging new molecular targets are just some of the reasons explaining this shift. Moreover, we show that the relative abundance of B2 sequences in heart and liver eccDNAs is higher than the relative abundance of the other repetitive sequence families studied. A pattern reversal checkerboard stimulus utilised SFs ranging from 0.1 to 28 cycles per degree (cpd).

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Are maternal hypertension and small-for-gestational age risk factors for severe intraventricular hemorrhage and cystic periventricular leukomalacia? Longitudinal data suggest that pretreatment levels of pain-related disability and changes in fear of movement/(re)injury are most important to immediate treatment outcomes and individual reliable change.

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Use of the nuc1 null mutant for analysis of yeast mitochondrial nucleoids. We refrained from offering prenatal testing in two other families, because either the disease did not link to chromosome 16 and/or normal phosphomannomutase activities were measured in fibroblasts from the proband. The correlation between PSI and grip strength suggests the potential contribution of PSI to grip force production and upper-extremity motor function.

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The amount of casein present after 5 days of incubation was found to be a measure of the prolactin concentration in the medium. The links between AKT and two intracellular proteolytic cascades: ubiquitination and autophagy. Association of HLA-E polymorphism with severe bacterial infection and early transplant-related mortality in matched unrelated bone marrow transplantation.

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The correspondence of the landmark points is determined from the Euclidean distance between the landmark points and the similarity between the local images that are centered at points at the same time. The morphology and proliferation rate of the muscle-derived MPCs was similar to bone-marrow derived MSCs. Nursing students need a good clinical practice environment in order to apply their knowledge and skills due to the fact that the clinical practice settings play an important role in the nursing profession. The internal diene 6a undergoes regioselective 1,2-hydrogenation of the double bond proximal to the homoallyl thioether moiety.

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Intensive insulin management and blood glucose monitoring independently predicted frequent but not severe hypoglycemia. In this report we examined RNA from five adult tissues: ovary, coelomocytes, intestine, tube feet, and spine for the presence of SM 50 transcripts and protein. Mathematical modelling can help to optimally organise the workload in the histopathology laboratory by predicting the performance of possible interventions before actual implementation.

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Quantitative evaluation of the function of the presynaptic apparatus of the rat in cold adaptation We have previously identified residues within protein kinase subdomain X in the MAP3K, MEKK1, that are critical for its interaction with the MAP2K, MKK4, and MEKK1-induced MKK4 activation. Occurrence of the 15-hydroxy derivative of dihomogammalinolenic acid in human platelets and its biological effect. After differential screening, a cDNA clone (named pGSH3) was isolated as a gene which is expressed only after the ischaemia insult. Presence and regulation of plasma with natriuretic and Na-K ATPase inhibitory properties in normotensive subjects

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Surgery is the first effective treatment for solitary fibrous tumor of the pleura with Doege-Potter syndrome and the completeness of the initial resection is the key to preventing recurrence. Our study is the osteoarchaeological basis for this, the first-ever report on benign bone neoplasm in a pre-modern East Asian population.

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The compounds were isolated by various chromatographic methods and their structures were elucidated through spectroscopic analysis and chemical and physical properties. The use of recombinant factor VIIa (NovoSeven) in a patient with a factor XI deficiency and a circulating anticoagulant.

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With the SD cycle, these calculations result in a mean unsigned error of less than 1 pK(a) units, with respective mean signed error and maximum unsigned error of less than 0.5 and 2 pK(a) units. To this end, we studied the effect of GABAergic and serotoninergic systems on hypothalamic catecholamine content at different stages of sexual development.

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A method of screening air and water samples for the chemical-warfare agent Sarin is developed using solid-phase microextraction (SPME)-gas chromatography (GC)-mass spectrometry (MS). Laminectomy has failed because it does not allow adequate decompression of epidural lesions anterior to the thecal sac.

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Due to strong variability of currents, backward simulations did not allow for the identification of particular source regions influencing given monitoring sites. Immunohistochemical deposition and distribution of fetal antigen 2 (FA2) was examined in normal brain tissue and in primary and metastatic tumors of the brain.

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This study confirms that silicone oil attenuates radiation dose in vitro, and may protect against radiation retinopathy clinically in patients, however it requires extensive surgical interventions. Previous descriptions of developing SCT-question banks were merely subjective. The traditional endoscopic approach involves resection of the inferior turbinate to perform an endoscopic medial maxillectomy, which can cause atrophic rhinitis and shrinking of the maxillary sinus, resulting in difficulty following these patients for recurrence in the office.

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They are formally equivalent, but use different-looking mathematical approaches, and are not causally equivalent: for a given problem KS can be a more suitable causal explanation than MLS, and vice versa. Blocking interhost transmission of influenza virus by vaccination in the guinea pig model. Thrombolysis with alteplase is used in acute ischemic stroke within 3 hours after symptom onset in many stroke centers, but experience remains limited in Europe. Herein, we describe a surgical approach for management of a pregnant woman with an ovarian tumor using laparoendoscopic single-site surgery with exteriorization. This article describes a simple concise technique for precise implant angulation.

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Phentermine plus topiramate for weight reduction: more tolerable and effective? Due to the medium polarity of triterpenic acids and dialcohols, different ethanol-water ratios were tested in order to select the optimum extractant composition for their solubilisation. Virulence of the various serotypes of pneumococci varies with adhesion, enzyme secretion, and resistance to phagocytosis. Evidence from recent studies indicates that in patients with diabetic nephropathy combined therapy with ACE inhibitors (ACEI) and AT1-receptor antagonists (ARB) results in more complete blockade of the renin-angiotensin-aldosterone system (RAS) than monotherapy, and reduces proteinuria. Analyses were conducted on 2083 children under 5 years old nested within 1641 households with eligible anthropometric measurements, using multilevel regression analysis.