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Cycloblastin (Cyclophosphamide)

Cycloblastin belongs to a class of drugs called alkylating agents. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. Cycloblastin works by stopping or slowing the growth or spread of certain cancer cells.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

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Prochlor, Vagimid, Neurontin, Neurolax, Dobupal, Nevimune, Scanovir, Sesaren, Gatilox, Shinun, Anafranil, Anzo, Rexan, Sequinan, Trevox, Galepsi, Amoxicure, Artevil, Cilamox, Baycip, Progut, Kalixocin, Prodec, Neomox, Oxyteracin,

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Compartmentalization of the minimal complex of actinorhodin polyketide synthase in coacervate liquid droplets produces enhanced yields of shunt polyketides under conditions of low and high ionic strength. In conclusion, the PCR-stop assay could be useful in detecting variation in DNA damage in specific genes. Alcoholic cardiomyopathy--an etiological factor in heart failure-generating cardiomegaly Two fluoroquinolone (FQ) antibiotics, enrofloxacin (ENR) and ciprofloxacin hydrochloride (CIP), and two marine microalgae, Platymonas subcordiformis and Isochrysis galbana, were investigated under irradiation with a high-pressure mercury lamp (HPML) in a laboratory-scale experiment. A concomitant increase in catalase antioxidant activity and decreased DNA oxidative damage indicate improved cellular redox status and a potential mechanism contributing to improved insulin sensitivity.

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These ambiguous experiences of their ED visits indicate a need for exploring possible ways of improving the situation for the chronically ill older person in ED. Trichophyton rubrum is a dermatophyte that causes tinea infection in adults and children but infection is surprisingly rare in the preterm infant. The measured effect was the time for clotting of plasma after initiation with thrombin. Genome Sequences of Populus tremula Chloroplast and Mitochondrion: Implications for Holistic Poplar Breeding.

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Elder abuse is under-recognized by emergency department (ED) providers, largely due to challenges distinguishing between abuse and accidental trauma. A study on the evaluation of anticoagulation status comparing of CHADS2 versus CHA2DS2-VASc scores in patients with non valvular atrial fibrillation in Xinjiang area

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In this study DITPA was given daily ip to adult Mct8KO mice to determine its effect on thyroid tests in serum and metabolism (total energy expenditure, respiratory exchange rate, and food and water intake). These findings suggest that interventions focused on emotional regulation may have the potential to reduce CAS among MSM. Molybdenum disulfide (MoS2) is a promising catalyst for hydrogen evolution reaction (HER) because of its unique nature to supply active sites in the reaction. The VLM syndrome is usually a benign, self-limited disease but occasionally severe ocular, pulmonary or CNS involvement may result.

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We report the first surviving case of neonatal hemochromatosis with renal tubular dysgenesis. The recent emergence of Chikungunya Virus (CHIKV) in the Americas constitutes a major public health problem on this continent, where the mosquito vector is widespread. The results are discussed with regard to implications for the reading capacity of the nondominant right hemisphere and also its putative contribution to normal reading. Human adrenal cells, H295R were exposed for 24h in a serum-free medium to various concentrations of cinnamaldehyde.

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To determine the efficacy of blue versus blue-green phototherapy using new light sources with narrow luminous spectra. Fast calculation of pairwise mutual information for gene regulatory network reconstruction. We utilized the olfactory system, which displays postnatal neurogenesis, as a model to investigate MeCP2 expression during development and after injury. Primary hypothyroidism occurred in three females (prevalence 0,2 pc) and nine patients were diagnosed hyperthyroid (prevalence 0,6 pc). We present here the updated version 2.2 of the HADDOCK portal, which offers new features such as support for mixed molecule types, additional experimental restraints and improved protocols, all of this in a user-friendly interface.

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We assessed the impact of geographic location, season, and exposure to ultraviolet light on disease severity by measuring national hospital IBD-related discharge rates. Multigene panel analysis identified germline mutations of DNA repair genes in breast and ovarian cancer. Here, we screened marine bacteria for glycosyltransferases using two methods: a one-pot glycosyltransferase assay method and a lectin-staining method. A secondary aim was to devise an automated computer-assisted method that allows the examiner to more easily identify the gingival sulcus contour on ultrasound images. Visual categorization of surface qualities of materials by capuchin monkeys and humans.

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Moderate correlations with global questions on micturition frequency and UI episodes supported the validity of the diary. The m/ri ratios in the superior mesenteric arterial trunks were significantly smaller in treated 4-month-old SHR and SHRSP than in WKY, although their blood pressures were not fully normalized. Each step of these scales is associated with preference weights. Behavioral and transcriptional patterns of protracted opioid self-administration in mice. This prospective, multicenter trial compared quantitative results of myocardial perfusion imaging and function using a high-speed single-photon emission computed tomography (SPECT) system with those obtained with conventional SPECT.

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DIAGNOSTIC AND THERAPEUTIC MANAGEMENT OF THE NEPHROTIC SYNDROMES OF INFANCY Craniosacral Therapy Shown Beneficial in Management of Chronic Neck Pain. Recent data suggest a decrease in circulating bile salts as well as changes to inflammatory markers and circulating cytokines. This spectral tuning strategy resulted in semi-synthetic photoprotein mutants with significantly altered bioluminescent properties. The technique clearly differentiates vitreous from PFCL and infusion fluid, and facilitates trimming of the vitreous base, draining of subretinal fluid and air/fluid exchange.

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Criteria of the severity of acute dichloroethane poisonings and the procedure for intensive therapy Retrospective case series of GHB intoxications seen in an urban ED. However, the association of MG with nemaline myopathy is rarely reported. Centrifugation permits the reappearance of fern-leaf crystallization.

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Weaker evidence supports an association with leukemia in electrical workers. The testicular weight of the FM-treated rats on D8 was a little but significantly higher than in the control group. When participants attempted to retrieve words from dictionary definitions in experiment 1, abstract words were associated with more omissions and more alternates than were concrete words. In this study, to explore a possible link between oral infection and Buerger disease, we investigated whether oral (periodontal) bacteria were present in occluded arteries removed from patients with characteristic Buerger disease. Furthermore, a laboratory experiment revealed that morphological color plasticity could explain much, but not all, of the observed fish color divergence.

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Critical issues with clinical research in children: the example of premature infants. Mean organ doses received by non-human primates undergoing whole thorax lung irradiations were calculated using a treatment planning system that is routinely used in clinical radiation oncology. An assessment of readiness for pre-implementation of electronic health record in Iran: a practical approach to implementation in general and teaching hospitals.

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Plasmid profile in oral Fusobacterium nucleatum from humans and Cebus apella monkeys. Treatment of the KIT-expressing SCLC-derived NCI-H526 cell line in vitro with SU11248 resulted in dose-dependent inhibition of stem cell factor-stimulated KIT phosphotyrosine levels and proliferation.

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Bone marrow cytology showed dysplasia of hematopoietic cells with abnormal high proportion of myeloblasts. Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1. The effects of these modifications on item hierarchy have not previously been analyzed. The calculated reaction free-energy profiles are in very good agreement with experimental measurements and are used to discern between different proposals for the general acid.

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In this article, imaging genetics literature on emotional face processing, reporting genetic effects of 5-HTTLPR in healthy volunteers is reviewed. Resin infiltration of early carious lesion in early childhood: a case report. The method described is suited above all for laboratories with large workload where a great number of resistance determinations must be carried out rapidly, precisely at a low cost.

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Vertical and oblique (lateral, anterior, and posterior) dislodging forces were measured at the beginning of the study (initial retention) and after 540 cycles of denture insertion and removal (final retention). Sustaining a hip fracture is associated with an increased mortality risk. The role of nitric oxide formation in organic nitrate-induced vasodilation and organic nitrate tolerance. Because it is a rare disease, uveitis is often overlooked, and the possible associations between uveitis and extra-ocular disease manifestations are not well known.

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FSHR transcript levels increased in parallel to FSHbeta levels from early spermatogenesis onwards, while LHR mRNA started to increase prior to any large changes in LHbeta expression. Over the years different algorithms have been developed to reduce right ventricular pacing.

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Effect of exercise training on tissue vitamin E and ubiquinone content. To investigate the KNDy hypothesis in humans, we assessed for the first time the effects of the coadministration of kisspeptin-54, NKB, and an opioid receptor antagonist, naltrexone, on LH pulsatility (surrogate marker for GnRH pulsatility) and gonadotropin release.

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The psychometric analyses included internal consistency, convergent, and divergent validity. One type of contrast enhancement, available in both systems, exaggerated lack of light at the peripheral area of the original image. We introduced the E1A gene into c-erbB-2/neu-overexpressing SKOV3.ip1 cells and found that the E1A-expressing ovarian cancer cell lines had decreased c-erbB-2/neu-encoded p185 expression and reduced malignancy, including a decreased ability to induce tumors in nu/nu mice. We conducted this systematic review and meta-analysis to summarize the evidence about commonly prescribed drugs and their association with weight change. The unique electronic, mechanical, and thermal properties of graphene are combined with the plasmonic properties of gold nanoparticle (AuNP) dimers, which are assembled using DNA origami nanostructures.

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As a result, pyloric stenosis rats showed hypergastrinemia, G-cell hyperplasia and D-cell hyperplasia with normal PGE2 concentration of gastric mucosa compared with sham operated rats. The registry of DAS sources is available at This modification alters the localization and/or the function of the targeted protein. The findings indicate that trachoma is present in all the Pacific Island countries screened. CD56, or neural cell adhesion molecule (NCAM), has been demonstrated recently as the tumor marker of the pulmonary neuroendocrine cell system.

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An induction furnace coupled to a Unicam SP90 atomic-absorption spectrophotometer is described for the determination of traces of volatile elements in solutions and volatile matrices. Platelet supplementation enhanced platelet aggregation in a dose-dependent manner while fibrinogen had no or reducing effect. To determine the current risk of internal radiation exposure after the Chernobyl accident, the (137)Cs body burden of the inhabitants of Bryansk Oblast, Russian Federation was evaluated, from 1998 to 2008.

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Distribution of malaria exposure in endemic countries in Africa considering country levels of effective treatment. This finding was corroborated by MD simulations where I27 was dragged from water into a nonpolar solvent, revealing details of the unfolding process at the water/nonpolar solvent interface. Prevalence of human immunodeficiency virus (HIV) antibody among apparently healthy pregnant women in Nigeria. Forum: reconstruction of the traumatic thumb in practice...the surgeon passes! CCK modulation of cerebellar afferents: dopaminergic involvement.

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The development of reliable diagnostic tool for assessing alcoholism is an utmost necessity in treating and preventing damage due to alcoholism to both individual and armed forces as alcoholism represents a serious health issue with major socioeconomic consequences. In this context, we examine the impact of geometry upon some recently reported phenomena, including the creation of viscous eddies, fluid flux into the EGL, as well as the role of the EGL in transmitting mechanical signals to the underlying endothelial cells.

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Newly emerging diseases include inflammatory bowel disease and gastroesophageal reflux. Rapid conditional targeted ablation model for hemolytic anemia in the rat.

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Angiotensin II and atrial natriuretic factor: cellular mechanisms in mammalian proximal tubule. Infertility studies are an important growing field, where new methods for the manipulation, enrichment and selection of sperm cells are required. Based on these simulation results, we proposed a new molecular model of cellular senescence--the two-process model. In this review, we discuss clinical and preclinical evidence supporting various emerging compounds that regulate penile erection both centrally (clavulanic acid, dopamine and melanocortin receptor agonists) and peripherally (novel PDE5I, soluble and particulate guanylil cyclase activators, rho-kinase inhibitors and maxi-K channel openers).

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In summary, the cardiac toxicity of digitalis substances produced by lower vertebrates is comparable with that induced by the glycosides. Indications for embolization treatment of tumors are not definitively established because of insufficient knowledge of tumor biology after embolization. These results suggest that the development of cardiotoxicity is dependent upon the quantity of digoxin delivered into the systemic circulation regardless of the plasma concentration. Measurement properties were evaluated per subscale according to the COSMIN taxonomy consisting of: reliability (internal consistency, test-retest reliability and measurement error), validity (structural validity, content validity and cross-cultural validity comparing the Dutch version to the English version) responsiveness and interpretation.

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On the stripe-patterned surfaces, above the lower critical solution temperature (LCST), the cells initially adhered and spread with an orientation along the pattern direction. Differences between the two groups were noted in cancer fatalism, perceived control over their participation in screening activities, and family history of cancer. Femoral access for endovascular aneurysm repair in obese patients. In this paper, we reconstruct the weighted and time-dependent network of counterparty risk in the OTC derivatives market of the United States between 1998 and 2012.

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State-specific mortality rates by state of residence varied between 2.1 and 79.9 deaths/1,000,000 general population. Synthesis and Monolayer Behaviors of Novel Hybrid Corynomycolic Acids Containing Semifluoroalkyl Groups. Neocarzinostatin induces an effective p53-dependent response in human papillomavirus-positive cervical cancer cells.

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Among women receiving risk reduction counseling and condoms in an HIV prevention program, diaphragm plus lubricant gel provision did not affect HPV incidence or clearance. We systematically reviewed clinical trials on the safety and efficacy of cefepime in pediatric patients in view of recent reports, which suggested that cefepime is associated with increased 30-day all-cause mortality rates. Amperometric detection of perphenazine at a carbon fiber micro-disk bundle electrode by capillary zone electrophoresis. The patients were divided into two groups, the viable group that showed one grade or more improvement (61 patients), and the non-viable group that showed no improvement (41 patients). Low NRF2 mRNA expression in spermatozoa from men with low sperm motility.

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Microtubule-Mediated Inositol Lipid Signaling Plays Critical Roles in Regulation of Blebbing. Evolutionary conservation of the insulinoma gene rig and its possible function. When the oil slick thickness or the oil concentration reaches a critical value, particles are mapped on slick thickness or node concentrations, and the calculations proceed in the Eulerian-Lagrangian mode. 8-bromo-cAMP bypasses the inhibitory effect of forskolin as well as AII.

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Allogenic blood transfusion and postoperative outcome -5-year experience in a digestive surgery unit Apoptosis and senescence were analysed using siRNA transfection, western blot and flow cytometry.

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These results, together with our previous observation that PHM immunoreactivity is present in human hypothalamus and pituitary stalk, suggest that PHM may play a physiological role in the regulation of ACTH secretion in humans. Host range factors, expressed by the poxvirus family, determine the host tropism of species, tissue, and cell specificity. To study CSF cytokines and chemokines as diagnostic biomarkers of active neuroinflammation, and assess their role in differentiating demyelinating, autoimmune, and viral encephalitis. The post-operative complications were related to preexisting risk factors.

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The signaling pathways behind the reshaping and migrating properties of the cytoskeleton in cancer cells involve a group of Ras-related small GTPases and their effectors, including the p21-activated kinases (Paks). For deer of the same age, both log antler weight and log antler specific gravity were related to body-weight in September and to body-weight gain between March and September. Some professions foster expectations that individuals cultivate their work identity above all other aspects of life. The aim of this study is to evaluate the clinical characteristics of SIR and compare it with other causes of rhabdomyolysis. High PAX7 sustains migration and invasiveness in ERMS cells by upregulating EPHA3 and EFNA1 and downregulating NCAM1 thus decreasing the neural cell adhesion molecule (NCAM)/polysialylated-NCAM ratio.

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The method is based on the reaction of p-aminophenol at ambient temperature with sodium sulphide in presence of an oxidant to produce a methylene blue-like dye. Cytokine production after influenza vaccination in a healthy elderly population. With the availability of a novel bioconjugation technology it is expected that multivalent O antigen conjugate vaccines can be produced at industrial scale.

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Further evaluation of the prognostic significance of basal and luminal cytokeratins in young women with breast cancer is warranted. Our data indicate that Spiral Array has benefits for covering tissue heterogeneity and preserving better morphology. A randomized controlled trial of salpingectomy prior to IVF in patients with hydrosalpinges has been conducted in Scandinavia. Delta activity in slow wave sleep is decreased in the 0.5-2 Hz frequency band only. Elevated serum microRNA-122/222 levels are potential diagnostic biomarkers in Egyptian patients with chronic hepatitis C but not hepatic cancer.

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Sample preparation: a crucial factor for the analytical performance of rationally designed MALDI matrices. Change was facilitated when there was acknowledgment of a need to do things differently by the NICU leadership. Mass-Up: an all-in-one open software application for MALDI-TOF mass spectrometry knowledge discovery.

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A series of conserved intra- and interchain disulfide bonds in the carboxyl-terminal region of the procollagen chains, or C-propeptide, has been hypothesized to play an important role in the nucleation and alignment of the chains. We demonstrate that density-dependent dispersal probability can act as a mechanism for coexistence of otherwise non-coexisting competitors.

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However, whether miR-497 is involved in inhibiting angiogenesis, which is critical for tumor growth and metastasis, is still unknown. G-6-PD level and azibiot 500 mg cenapred surface nanoscopy: a novel approach in ergonomic stress management of female labours in Bengal suburbs performing manual material handling.

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The objective of our study is to evaluate the importance of TGF-beta(1) in regulating epithelial cell repair in asthma. The expression of IZAg1 is enhanced by dibutyryl-cyclic AMP or ACTH in vitro and by in vivo ACTH treatment. An important regulator of actin polymerization is the actin-related protein2/3 (Arp2/3) complex, which nucleates the polymerization of new actin filaments. Once learned, the nonfuzzy features of a pattern can be classified. The present study aimed to investigate the involvement of molecule NO in naloxone-induced pain and its possible interaction with naloxone into cortical area 1 (CA1) poviral suspension via oral of hippocampus.

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Glutamate effects on calcium homeostasis in cerebellar granule cells in primary cultures grown under depolarizing warfarina e vitamin a kids and nondepolarizing conditions. The protozoan parasite Leishmania often responds to drug pressure by amplifying part of its genome.

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Cutaneous angiosarcoma of the face and scalp is a rare malignant vascular tumor that affects mostly Caucasian elderly males. The effects of the carbon and nitrogen sources, initial pH and incubation temperature on laccase production by the endophytic fungus Monotospora sp. Complete vs Culprit-Only Percutaneous Coronary Intervention in STEMI With Multivessel Disease: A Meta-analysis and Trial Sequential Analysis of Randomized Trials. To analyse whether the mean nuclear area of the 10 largest nuclei (MNA-10), the mitotic activity index (MAI), and Ki-67 immunoquantitative features negazole 250 mg have additional value to discriminate different grades of T(A,1) transitional cell carcinoma (TCC) of the urinary bladder.