Anxinil is only found in individuals that have used or taken this drug. It is an anxiolytic agent and a serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the benzodiazepines, but it has an efficacy comparable to diazepam. [PubChem]Anxinil binds to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus, thus inhibiting the firing rate of 5-HT-containing neurons in the dorsal raphe. Anxinil also binds at dopamine type 2 (DA2) receptors, blocking presynaptic dopamine receptors. Anxinil increases firing in the locus ceruleus, an area of brain where norepinephrine cell bodies are found in high concentration. The net result of Anxinil actions is that serotonergic activity is suppressed while noradrenergic and dopaminergic cell firing is enhanced.
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