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Ledifos (Ribavirin)
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Ribavirin

Ledifos is a high-class antiviral medicine which is taken to treat such diseases as severe RSV infection, hepatitis C infection (used in conjunction with sofusbuvir or peginterferon alfa-2b or peginterferon alfa-2a) and other viral infections. Rebetol is an anti-viral drug indicated for severe RSV infection, hepatitis C infection and other viral infections. Rebetol is manufactured by Merck Sharp and Dome (a subsidary of Merck and Co., Inc.). The active ingredient, Ledifos is a professional grade drug, which when metabolized resembles purine RNA nucleotides. In this form it interferes with RNA metabolism required for replication Rebetol. Ledifos helps the immune system fight the virus and makes it harder for the virus to reproduce within the body. Rebetol is prescribed in combination with other medications such as sofusbuvir and peginterferon alfa 2a/2b for preventing hepatitis C virus (HCV) cells from multiplying in your body. Treatment of HCV genotypes 1, 2, 3 and 4 is possible with Rebetol, however it is never used on its own.

Other names for this medication:
Ribavirin, Rebetol, Copegus, Alfater, Beclabuvir, Boceprevir, Daclatasvir, Daklinza, Dasabuvir, Elbasvir, Filibuvir, Hepcinat, Hepcvir, Incivek, Kipferon, Ledifos, Ledipasvir, Miravirsen, Multiferon, Olysio, Ombitasvir, Paritaprevir, Pegasys, Pegetron, Pegintron, Rebetron, Resof, Setrobuvir, Simeprevir, Sofab, Sofovir, Sovaldi, Sylatron, Technivie, Telaprevir, Veldona, Victrelis, Viroclear, Zepatier,

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Repeated measures of nested data were used to model main effects of exposure to Just/Us and time by treatment interaction. Computer-aided assessment of head computed tomography (CT) studies in patients with suspected traumatic brain injury. The data from all processes were coded, grouped, interpreted and thematically analysed for emerging themes and patterns, independently by the researcher (TP). This discrepancy along with its implications are discussed in this report.

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Plasticity of cancer cells, manifested by transitions between epithelial and mesenchymal phenotypes, represents a challenging issue in the treatment of neoplasias. Synthesis of Nanoporous Cubic In(CN)(3) and In(1)(-)(x)()Ga(x)()(CN)(3) and Corresponding Inclusion Compounds. Erratum: Improving physical health for people taking antipsychotic medication in the Community Learning Disabilities Service. Therefore, we propose that proteogenomic projects are designed so that the generated peptides can also be used to create a comprehensive protein atlas that quantitatively catalogues protein abundance changes during development and in response to environmental stimulus.

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The paradigm for the latitudinal gradient in species richness is that it is unimodal with a tropical peak. The aim of our study was to compare a new molecular approach based on the quantification of the expression of non-imprinted bi-allelic gene (NIPA1 and OCA2) with in house MS-PCR and the MS-MLPA test. After cryopreservation for 1 month, cell viability, surface adherence ability, alkaline phosphatase activity and mineralized nodule formation were assessed. To compare and evaluate Candida lytic effects of denture cleansers.

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Central skull base osteomyelitis is clinically difficult to distinguish from malignancy. Practical approach to prepare solid dispersion drug product using spherical silicate. A case of sideburn reconstruction using a temporoparieto-occipital island flap. Both ZEB proteins bind to Smads, but while ZEB-1/deltaEF1 synergizes with Smad proteins to activate transcription, promote osteoblastic differentiation and induce cell growth arrest, the highly related ZEB-2/SIP1 protein has the opposite effect. Where the structure of the septal cartilage is destroyed, a sufficient L-strut must be reconstructed.

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However, relatively little is known about the gradual changes in hippocampal structure, and its behavioral consequences, over the course of repeated stress. The use of intraoperative MRI (iMRI) may lead to improved results. The first clinical case of DT104 infection at the Ontario Veterinary College was identified in 1997. The continuing challenge is partly due to the poor forecasting potential of models of CNS diseases, as well as the lack of reproducibility of published studies, and greater need to increase focus on pharmacodynamic end points.

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Cell-free DNA testing: inadequate implementation of an outstanding technique. Protein cargoes that contain a classic nuclear localization signal (NLS) are transported into the nucleus through binding to a heterodimeric receptor comprised of importin/karyopherin alpha and beta. Bovine growth hormone-transgenic mice have major alterations in hepatic expression of metabolic genes.

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Utility of flow cytometry studies in the management of patients with multiple myeloma. A European perspective on nosocomial urinary tract infections II. The use of solid-state nuclear magnetic resonance (NMR) as a tool to determine the structure of membrane molecules is reviewed with a particular emphasis on techniques that provide information on orientation or order. To report a previously undescribed complication of group B streptococcal infective endocarditis, which was lumbar facet joint arthritis. This occurs with similar excitatory synaptic drive throughout postnatal maturation, but with a greater prevalence at younger ages.

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Here, we describe the development of a novel application based on Unity3D and smart devices, e.g., smartphones or tablet devices, that can be used to conduct motor learning experiments at any time and in any place, without requiring a large budget and wide open space and without the burden of travel on subjects. This new myeloid subset may have an important role in the in vitro and in vivo production of Treg cells for the treatment of autoimmune diseases, and in either the prevention or control of allograft rejection. Responses to and Outcomes of Treatment of Autoimmune Cerebellar Ataxia in Adults. Our aim was to quantitate day-to-day changes in the tear and meibum lipid profile of individual subjects in a pilot study of healthy humans. Quantitative calculations on systems of the magnitude of proteins are becoming a realistic possibility, an achievement that would have been unimaginable to the early pioneers of quantum chemistry.

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Moreover, lipid profile and renal oxidative stress were assessed. Understanding the underlying mechanism of thrombus formation and its components is critical for effective prevention and treatment of ischemic stroke. This caging is dependent on the emission of the QD, but it is effective through the visible spectrum into the nIR, offering a large array of new colors for photoactivatable probes. POSTOPERATIVE JEJUNAL ULCER: A STUDY OF TWENTY-THREE CASES OPERATED UPON AT THE PRESBYTERIAN HOSPITAL, NEW YORK.

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Cardiac complications of anti-malarial drugs are uncommon, and most of the time are the result of a long-term exposition. Transactions of the Philadelphia Academy of Surgery-Stated Meeting held November 7, 1932. Tissue specific expression of hBcl-2 in immunoassays validated the transgenic animal model. Two group A rotaviruses (ISU-64 and ISU-65) with subgroup I antigen were isolated from pigs with diarrhea and were shown by two-way neutralization tests to be two new serotypes of porcine rotavirus.

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The allosteric catabolic ornithine carbamoyltransferase (OTCase) from Pseudomonas aeruginosa, a dodecamer build up of four trimers of identical subunits, shows strong carbamoylphosphate homotropic co-operativity. Pathophysiological and clinical aspects of breathing after stroke. The National Public Health performance Standards Program (NPHPSP) has developed assessment instruments based on the ten essential public health services (EPHS) for state and local health departments. Common chitotriosidase duplication gene polymorphism and clinical outcome status in sarcoidosis.

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We examined the high body weight-selected mouse lines NMRI8 and DU6i and the intercross populations NMRI8 x DBA/2 and DU6i x DBA/2. Prospective evaluation of the Sunshine Appendicitis Grading System score.

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This review summarizes the pharmacokinetic and microbiologic properties of ceftaroline, as well as the safety and efficacy data that led to its approval by the FDA in 2010 and the European Commission in 2012. Compared with JLPS cells, the increased glucose uptake in JLPR cells (with upregulated glucose transporters, increased antioxidant enzyme activity, and altered cell cycling) conferred ascorbate-induced cytotoxicity and resistance. Echocardiography revealed a dilated left ventricle and severe left ventricular dysfunction. Here, we show that the insulin-regulated transcription factor dFOXO positively modulates dilp6 mRNA in adult fat body.

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However, TNF did not increase either RT activity in MT-4 cell supernatants or viral antigen expression in HUT-78 cells. Liver transplantation for familial amyloidotic polyneuropathy (FAP): a single-center experience over 16 years.

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This growth posed unique challenges and required novel solutions. The authors surveyed the comparative psychotherapy process literature to identify core features of psychotherapy shared across schools and differentiate those features from the defining features of psychodynamic therapy and cognitive-behavioral therapy.

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The results were examined in terms of sex, age, surgical history, and any evidence of inflammatory or neoplastic diseases. Synergism between ERalpha transactivation function 1 (AF-1) and AF-2 mediated by steroid receptor coactivator protein-1: requirement for the AF-1 alpha-helical core and for a direct interaction between the N- and C-terminal domains. Electro-optically switchable spatial-mode entangled photon pairs using a modified Mach-Zehnder interferometer. HTLV-I, the causative agent of Adult T cell Leukemia, has recently been found to be associated with chronic neuromyelopathies common in tropical areas and in Japan.

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The effectiveness of benzimidazole-levamisole combination drenches in the presence of resistance to both benzimidazole and levamisole anthelmintics in New Zealand sheep. Parasite species can adapt to ecological, behavioral, physiological and biochemical traits of a particular host species. To our knowledge, this is the first case report to demonstrate cutaneous origin melanoma harboring a GNA11 Q209L mutation. Surgically placed radiopaque clips appear to be useful for determining adequate boost field in the BCT using the CT-S and help increase the local control rate. Inhibitory Effect of Anti-rheumatic Drug Iguratimod for Hepatocellular Carcinogenesis by Inhibition of Serum Interleukin-8 Production.

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On-line preconcentration and determination of copper, lead and chromium(VI) using unloaded polyurethane foam packed column by flame atomic absorption spectrometry in natural waters and biological samples. Patient state index and cerebral blood flow changes during shoulder arthroscopy in beach chair position. A comprehensive literature review of historical texts, peer review publications, and abstracts was used to compile a listing of the existing genito-urinary fistula classification systems.

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To identify the carotid artery system, red carbon ink was injected, or vascular casts were made by injection of Mercox resin and observed by scanning electron microscopy. Three basic methods of preconcentration of organic atmospheric pollutants, viz. In two out of six animals a mild water diuresis developed at about 50 min post-infusion. No differences in EMG activity were found during swallowing of saliva when different sections of the occlusal splints were used. Passion in sport: on the quality of the coach-athlete relationship.

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The results suggest that a priori knowledge of corneal thickness can be utilized for accurate assessments of corneal tissue water content. Restaurants in general, rather than specific categories of restaurant, expose patrons to excessive portions that induce overeating through established biological mechanisms. Such a reduction is also observed when only the insA gene is overexpressed in trans. The phytophagous insects of the Tephritidae family offer different case histories of successful invasions. In vivo, at 15 min following oral dose of 50 mg/kg ERY, an oral dose 20 mg/kg NMD was given to rats, plasma concentrations of NMD were determined.

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Fractionated EBRT has a role in the management of extensive intracranial and/or spinal cord disease, the adjuvant treatment of residual postoperative disease, and the treatment of recurrence. Health care professionals contribute to the experience of being involved. The optical system point spread function (PSF) is first defined, and methods to minimize the effects of the optical system are discussed. In this paper, the system was investigated using the extraction scheme of Hieltjes and Lijklema to study distribution of phosphorus in three certified reference materials (CRMs).

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Compelling evidence indicates that these effectors directly hijack or manipulate refined host physiological processes to promote the successful parasitism of host plants. Fresh cadaver dissections were carried out to accurately determine the anatomy.

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Early aggressive management of brain, dural, and craniomaxillofacial injuries should return the patient to a highly functional neurological status and restore an acceptable outward appearance. Experimental Execution of the Simulated Pivot-Shift Test: A Systematic Review of Techniques. Brain responses to angry vs neutral faces or emotional vs neutral scenes were examined with fMRI prior to initiation of CBT. Construction of recipient strain of expression-secretion system in filamentous fungi Ten-millimeter stitches of 0-braided polyester suture in the model were also tested.

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Spinal cord stimulation improved the changes occurring in latencies and amplitudes in the experiment group. This strategy is highly sensitive, and useful to determine whether or not a putative lectin domain may have sugar-binding ability. The approach can be successfully applied for studying equilibrium systems, which cannot be treated with classical methods like Benesi-Hildebrand method due to the presence of systematic errors. Analysis of variance (ANOVA) gave significant results in Hb and HbF levels.

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Findings from cohort studies investigating the association between rice consumption and risk of chronic diseases or mortality have been inconsistent. Pain scores on one day before the surgery, on one day after the surgery and at the end of the follow-up were recorded using VAS. Matrix effect of barium on spectral line intensities and detection limits in inductively coupled plasma atomic emission spectroscopy. Its genome encodes a number of positive, differential, and negative regulatory genes, whose interplay appears to be directed at maintaining a steady, low-level virus expression.

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To determine the repair half-time (T1/2), a speed parameter of sub-lethal damage repair (SLDR), of human nasopharyngeal carcinoma (NPC) cell lines CNE1, HONE1, C666-1 and CNE2. Two patients had an unusual swirling and serpiginous pattern of increased attenuation superimposed on a low-attenuation background.

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Surgical treatment of clinical N1 non-small cell lung cancer: ongoing controversy over diagnosis and prognosis. It has been shown that the relatively low concentrations of proline (0.1 M) have a slight accelerating effect on thermal aggregation of glycogen phosphorylase b (Phb) from rabbit skeletal muscle registered by the accumulaton of the aggregated protein. Development of a scalable suspension culture for cardiac differentiation from human pluripotent stem cells. A 25 year old woman with a 15-year history of paroxysmal nocturnal haemoglobinuria developed transient pancytopenia following infection with human parvovirus B19.

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In such designs, enrollment would initially be open to a broad patient population with the option to restrict future enrollment, following an interim analysis, to only those biomarker subgroups that appeared to be benefiting from the experimental therapy. All adult nonintensive care inpatients for whom new antimicrobials were prescribed during a 2-week period were monitored throughout their hospitalization. Management strategies that lowered bioaccumulation rates also reduced ecosystem services. Expression and characterization of RNA-dependent RNA polymerase of Ectropis obliqua virus.

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Prevalence of diabetes increased inversely with income, especially among women. Thus, p53 posttranslational modification modulates only one of the two binding sites for p300 Taz2. The process consisted of a first step performed by selected fungal biomasses, mainly devoted to the effluent decolourisation, and of a subsequent stage by means of activated sludge, in order to reduce the remaining COD and toxicity. Transcatheter closure of secundum atrial septal defects using the Amplatzer septal occluder in adult patients: our first clinical experiences Prenatal diagnosis of a true umbilical cord knot in a fetus with intrauterine growth restriction and placenta accreta.

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Addition of osteopontin to osteoclasts transduced with Cdc42Val12 or transduction of osteoclasts with both RhoVal14 and Cdc42Val12 augments the formation of WASP-Arp2/3 complex and actin ring. Among them, the orbitofrontal cortex (OFC) seems to be particularly relevant as demonstrated by several neuropsychological and neuroimaging investigations. Period focusing induced by network feedback in populations of noisy integrate-and-fire neurons. These findings--albeit limited to a single case--suggest that tumors lacking LKB1 expression and/or endowed with an highly glycolytic phenotype might develop large necrotic areas following combined treatment with metformin plus bevacizumab. Three-dimensional chest computed tomography was used to identify the aberrant vessels.

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Cardiomyocyte contractility is needed for the heart to pump blood, so measuring the contractile forces of cardiomyocytes is a straightforward way to assess their function. They must be early diagnosed because they modify therapeutic options. Although there is no reported evidence, it is widely presumed that long term consumption of such milk leads to adverse health consequences.

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However, incubation of CA complexes from newly emerged females with Aedes-AT plus FA resulted in very high production of JH III. Determination of the scope and character of the opinions of investigated students in the organizational and substantial dimension concerning bridging studies carried out in the first experimental cycle of this form of education in Poland. Several studies have demonstrated an association between body mass index (BMI) and warfarin therapeutic dose, but none evaluated the association of BMI with the clinically important outcome of major bleeding in a community setting.

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Endoscopic Submucosal Dissection for Early Gastric Cancer: Getting It Right! Higher prevalence rates of both respiratory symptoms and personal risk factors were recorded in Urban Antwerp, Berendrecht-Zandvliet (harbour area) and Zwijndrecht (industrial area) than in Suburban Antwerp, Essen and Kasterlee (both rural). MP originate from different cellular lineages, principally from platelets in blood, and may expose phosphatidylserine (PS).

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By skipping any enrichment step and avoiding the use of labelling agent, this approach based on the Surface Plasmon Resonance imaging of the microarrays turns out to be much faster and more cost effective by comparison with standardized methods. Transformants that survive this phase emerge as fully malignant cells and usually contain mutations that disable the p53 tumor suppressor pathway. The gene structure of PG V appears to be primarily related to known lignin peroxidase genes, while the encoded mature 339-residue protein has several characteristics in common with manganese peroxidases. Uraemic pruritus (UP) is one of the most common complications in patients with end-stage renal disease (ESRD) undergoing dialysis and greatly undermines their quality of life.

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We propose that drugs targeting ASC can be developed as a combination therapy complementing conventional cancer treatments. The results from this study support extending the efficacy findings with qHPV vaccine to 9vHPV vaccine in men aged 16-26years.

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Diet had no influence on the quantities of endogenous amino acids or endogenous faecal N excreted. Effects of dexamethasone and colostrum intake on the somatotropic axis in neonatal calves.

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This result implies that Lps gene controls the innate resistance of murine macrophages against the bacteria. Mechanisms of direct inhibitory action of propofol on uterine smooth muscle contraction in pregnant rats. A peculiar spatial relationship of 5-HT cells with the vascular network of the IL is suggested. Northern blot analysis resulted in a 3.6-kb transcript for mouse skeletal and heart muscle. Spectrum of Histomorphologic Findings in Liver in Patients with SLE: A Review.

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The velocity of neurofilament transport was not significantly different from controls in portions of the nerve proximal to the Trembler graft, but there was a reduction in neurofilament transport rates upon entering the Trembler graft. These studies demonstrate that mu-conotoxin GIIIA can be used to define the guanidinium toxin binding site and will be a useful ligand for understanding functionally important differences between Na channel subtypes. Benign acute childhood myositis as a complication of influenza B and its differential diagnosis The objective of this study conducted a comprehensive systematic review that synthesizes and interprets primary observational studies in order to elucidate the relationship between psoriasis and metabolic syndrome.

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Our findings enable compensating for the fluctuations clarithromycin dosage iv tylenol using a feedback scheme to achieve stable frequency downconversion. Behavioural, electrophysiological and receptor binding experiments gradually led to the idea that buspirone owes much of its anxiolytic activity to its ability to attenuate central 5-hydroxytryptamine neurotransmission. hGTSE-1 knock-down by small interfering RNA resulted in a S/G2-specific increase of p53 levels as well as cell sensitization to DNA damage-induced apoptosis during these phases of the cell cycle.

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In order to elucidate the interactions between the monoamine systems and the DMH, we studied the effects of subjecting rats to the fear-potentiated startle test, a commonly used test of anxiety in rats, on the NE, DA, and 5-HT levels in the DMH. After resection, CABG under cardiopulmonary bypass was performed. Both models demonstrated that in the face of corneal injury, CEs favored corneal healing, topcef syrup recipes whereas BAK was deleterious. The aim of this study was (1) to investigate the effect of different chainring shapes on sagittal knee joint moment and sagittal lower limb joint powers and (2) to investigate whether alterations are affected by cadence and workload.

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This review addresses the relationship between modifications in membrane phospholipid composition (MPC) and alterations in dopaminergic, serotonergic and cholinergic neurotransmitter systems gabaran prospect capsule in schizophrenia. Twenty patients with sarcoid and sarcoidal reactions of the orbit underwent biopsy, excision of localized mass, and systemic and local treatment at a tertiary referral center. Furthermore, this review summarizes the results of clinical trials which used CXCR2 inhibitors. This has raised speculations whether resistance of tumor cells to oHSV therapy may be a limiting factor. Post-transplant malignant lymphoma with monoclonal immunoglobulin gene rearrangement and polyclonal Epstein-Barr virus episomes.

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Concomitant with the obesity epidemic, more adolescents are developing OSAS. One hypothesis for the development of sensory profiles is that distinct pathophysiological mechanisms of pain generation produce specific sensory abnormalities. In this article the impact of six neurotrophic factors (BDNF, CNTF, GDNF, NGF, NT3 or VEGF) on axon regeneration was compared after delivery to a 1cm long nerve autograft by gene therapy. Primary motivations were duty and responsibility, guilt and social pressure, and altruism. But the protein degradation rate was also obviously increased on acyclovir tabletas 200 mg dosis jewelers 2 PBD.

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Experimental studies of tolerance doxepin cream uses to intravitreal perfluoro-n-octane liquid. This article evaluates the complication rate of the scalp donor site in the treatment of deep burns in the Beverwijk Burn Centre.